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A novel inhibitor of the mitochondrial respiratory complex I with uncoupling properties exerts potent antitumor activity - Cell Death & Disease
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Cancer cells are highly dependent on bioenergetic processes to support their growth and survival. Disruption of metabolic pathways, particularly by targeting the mitochondrial electron transport chain complexes (ETC-I to V) has become an attractive therapeutic strategy. As a result, the search for clinically effective new respiratory chain inhibitors with minimized adverse effects is a major goal.
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