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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood - Nature Microbiology

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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood - Nature Microbiology

Matching donor and recipient blood groups based on red blood cell (RBC) surface ABO glycans and antibodies in plasma is crucial to avoid potentially fatal reactions during transfusions. Enzymatic conversion of RBC glycans to the universal group O is an attractive solution to simplify blood logistics and prevent ABO-mismatched transfusions. The gut symbiont Akkermansia muciniphila can degrade mucin O-glycans including ABO epitopes.

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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood - Nature Microbiology

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Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood - Nature Microbiology

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