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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors - Nature Neuroscience

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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors - Nature Neuroscience

Compulsive behaviors have been associated with striatal hyperactivity. Parvalbumin-positive striatal interneurons (PVIs) in the striatum play a crucial role in regulating striatal activity and suppressing prepotent inappropriate actions. To investigate the potential role of striatal PVIs in regulating compulsive behaviors, we assessed excessive self-grooming—a behavioral metric of compulsive-like behavior—in male Sapap3 knockout mice (Sapap3-KO).

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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors - Nature Neuroscience

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Closed-loop recruitment of striatal interneurons prevents compulsive-like grooming behaviors - Nature Neuroscience

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