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Vimentin filaments integrate low-complexity domains in a complex helical structure - Nature Structural & Molecular Biology

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Vimentin filaments integrate low-complexity domains in a complex helical structure - Nature Structural & Molecular Biology

Intermediate filaments (IFs) are integral components of the cytoskeleton. They provide cells with tissue-specific mechanical properties and are involved in numerous cellular processes. Due to their intricate architecture, a 3D structure of IFs has remained elusive. Here we use cryo-focused ion-beam milling, cryo-electron microscopy and tomography to obtain a 3D structure of vimentin IFs (VIFs).

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Vimentin filaments integrate low-complexity domains in a complex helical structure - Nature Structural & Molecular Biology

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Vimentin filaments integrate low-complexity domains in a complex helical structure - Nature Structural & Molecular Biology

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