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9 days ago

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3C methods in cancer research: recent advances and future prospects - Experimental & Molecular Medicine

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3C methods in cancer research: recent advances and future prospects - Experimental & Molecular Medicine

In recent years, Hi-C technology has revolutionized cancer research by elucidating the mystery of three-dimensional chromatin organization and its role in gene regulation. This paper explored the impact of Hi-C advancements on cancer research by delving into high-resolution techniques, such as chromatin loops, structural variants, haplotype phasing, and extrachromosomal DNA (ecDNA). Distant regulatory elements interact with their target genes through chromatin loops.

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3C methods in cancer research: recent advances and future prospects - Experimental & Molecular Medicine

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3C methods in cancer research: recent advances and future prospects - Experimental & Molecular Medicine

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