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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair - Nature Structural & Molecular Biology

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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair - Nature Structural & Molecular Biology

Current models suggest that DNA double-strand breaks (DSBs) can move to the nuclear periphery for repair. It is unclear to what extent human DSBs display such repositioning. Here we show that the human nuclear envelope localizes to DSBs in a manner depending on DNA damage response (DDR) kinases and cytoplasmic microtubules acetylated by α-tubulin acetyltransferase-1 (ATAT1).

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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair - Nature Structural & Molecular Biology

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DNA double-strand break–capturing nuclear envelope tubules drive DNA repair - Nature Structural & Molecular Biology

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