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RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives - Blood Cancer Journal

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RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives - Blood Cancer Journal

NRAS and KRAS activating point mutations are present in 10–30% of myeloid malignancies and are often associated with a proliferative phenotype. RAS mutations harbor allele-specific structural and biochemical properties depending on the hotspot mutation, contributing to variable biological consequences.

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RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives - Blood Cancer Journal

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RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives - Blood Cancer Journal

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