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Targeting KRAS in cancer - Nature Medicine

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Targeting KRAS in cancer - Nature Medicine

RAS family variants—most of which involve KRAS—are the most commonly occurring hotspot mutations in human cancers and are associated with a poor prognosis. For almost four decades, KRAS has been considered undruggable, in part due to its structure, which lacks small-molecule binding sites. But recent developments in bioengineering, organic chemistry and related fields have provided the infrastructure to make direct KRAS targeting possible.

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Targeting KRAS in cancer - Nature Medicine

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