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Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease - Communications Biology

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Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease - Communications Biology

Bile infarct is a pivotal characteristic of obstructive biliary disease, but its evolution during the disease progression remains unclear. Our objective, therefore, is to explore morphological alterations of the bile infarct in the disease course by means of multiscale X-ray phase-contrast CT. Bile duct ligation is performed in mice to mimic the obstructive biliary disease. Intact liver lobes of the mice are scanned by phase-contrast CT at various resolution scales.

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Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease - Communications Biology

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Multiscale X-ray phase-contrast CT unveils the evolution of bile infarct in obstructive biliary disease - Communications Biology

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