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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin - Nature Communications

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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin - Nature Communications

Several studies have suggested the imprinting of SARS-CoV-2 immunity by original immune challenge without addressing the formation of the de novo response to successive antigen exposures. As this is crucial for the development of the original antigenic sin, we assessed the immune response against the mutated epitopes of omicron SARS-CoV-2 after vaccine breakthrough.

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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin - Nature Communications

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Vaccination impairs de novo immune response to omicron breakthrough infection, a precondition for the original antigenic sin - Nature Communications

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