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Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial - Nature Cancer

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Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial - Nature Cancer

In this prospective, interventional phase 1 study for individuals with advanced sarcoma, we infused autologous HER2-specific chimeric antigen receptor T cells (HER2 CAR T cells) after lymphodepletion with fludarabine (Flu) ± cyclophosphamide (Cy): 1 × 108 T cells per m2 after Flu (cohort A) or Flu/Cy (cohort B) and 1 × 108 CAR+ T cells per m2 after Flu/Cy (cohort C). The primary outcome was assessment of safety of one dose of HER2 CAR T cells after lymphodepletion.

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Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial - Nature Cancer

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Autologous HER2-specific CAR T cells after lymphodepletion for advanced sarcoma: a phase 1 trial - Nature Cancer

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