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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons - Nature Communications

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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons - Nature Communications

An inter-regional cortical tract is one of the most fundamental architectural motifs that integrates neural circuits to orchestrate and generate complex functions of the human brain. To understand the mechanistic significance of inter-regional projections on development of neural circuits, we investigated an in vitro neural tissue model for inter-regional connections, in which two cerebral organoids are connected with a bundle of reciprocally extended axons.

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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons - Nature Communications

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Complex activity and short-term plasticity of human cerebral organoids reciprocally connected with axons - Nature Communications

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