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System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning - Cell Research

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System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning - Cell Research

The suprachiasmatic nucleus (SCN) is the mammalian central circadian pacemaker with heterogeneous neurons acting in concert while each neuron harbors a self-sustained molecular clockwork. Nevertheless, how system-level SCN signals encode time of the day remains enigmatic. Here we show that population-level Ca2+ signals predict hourly time, via a group decision-making mechanism coupled with a spatially modular time feature representation in the SCN.

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System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning - Cell Research

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System-level time computation and representation in the suprachiasmatic nucleus revealed by large-scale calcium imaging and machine learning - Cell Research

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