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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology

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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology

Although messenger RNA (mRNA) has proved effective as a vaccine, its potential as a general therapeutic modality is limited by its instability and low translation capacity. To increase the duration and level of protein expression from mRNA, we designed and synthesized topologically and chemically modified mRNAs with multiple synthetic poly(A) tails.

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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology

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Branched chemically modified poly(A) tails enhance the translation capacity of mRNA - Nature Biotechnology

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