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Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors - Nature Biotechnology

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Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors - Nature Biotechnology

CRISPR–Cas9 paired with adeno-associated virus serotype 6 (AAV6) is among the most efficient tools for producing targeted gene knockins. Here, we report that this system can lead to frequent concatemeric insertions of the viral vector genome at the target site that are difficult to detect. Such errors can cause adverse and unreliable phenotypes that are antithetical to the goal of precision genome engineering.

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Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors - Nature Biotechnology

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Genome engineering with Cas9 and AAV repair templates generates frequent concatemeric insertions of viral vectors - Nature Biotechnology

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