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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia - Nature Structural & Molecular Biology

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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia - Nature Structural & Molecular Biology

The nine different membrane-anchored adenylyl cyclase isoforms (AC1–9) in mammals are stimulated by the heterotrimeric G protein, Gαs, but their response to Gβγ regulation is isoform specific. In the present study, we report cryo-electron microscope structures of ligand-free AC5 in complex with Gβγ and a dimeric form of AC5 that could be involved in its regulation.

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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia - Nature Structural & Molecular Biology

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Structure of adenylyl cyclase 5 in complex with Gβγ offers insights into ADCY5-related dyskinesia - Nature Structural & Molecular Biology

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