Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization - Nature Metabolism

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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization - Nature Metabolism

The obesity epidemic continues to worsen worldwide, driving metabolic and chronic inflammatory diseases. Thiazolidinediones, such as rosiglitazone (Rosi), are PPARγ agonists that promote 'M2-like' adipose tissue macrophage (ATM) polarization and cause insulin sensitization. As ATM-derived small extracellular vesicles (ATM-sEVs) from lean mice are known to increase insulin sensitivity, we assessed the metabolic effects of ATM-sEVs from Rosi-treated obese male mice (Rosi-ATM-sEVs).

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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization - Nature Metabolism

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Adipose tissue macrophages secrete small extracellular vesicles that mediate rosiglitazone-induced insulin sensitization - Nature Metabolism

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