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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy - Nature Immunology

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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy - Nature Immunology

The organization of immune cells in human tumors is not well understood. Immunogenic tumors harbor spatially localized multicellular 'immunity hubs' defined by expression of the T cell-attracting chemokines CXCL10/CXCL11 and abundant T cells. Here, we examined immunity hubs in human pre-immunotherapy lung cancer specimens and found an association with beneficial response to PD-1 blockade.

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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy - Nature Immunology

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Human lung cancer harbors spatially organized stem-immunity hubs associated with response to immunotherapy - Nature Immunology

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