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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease - Genes & Immunity

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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease - Genes & Immunity

Meniere Disease (MD) is a chronic inner ear disorder characterized by vertigo attacks, sensorineural hearing loss, tinnitus, and aural fullness. Extensive evidence supporting the inflammatory etiology of MD has been found, therefore, by using transcriptome analysis, we aim to describe the inflammatory variants of MD. We performed Bulk RNAseq on 45 patients with definite MD and 15 healthy controls. MD patients were classified according to their basal levels of IL-1β into 2 groups: high and low.

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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease - Genes & Immunity

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Cytokine profiling and transcriptomics in mononuclear cells define immune variants in Meniere Disease - Genes & Immunity

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