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Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer - Nature Synthesis

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Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer - Nature Synthesis

In recent years there has been a surge in the development of methods for the synthesis of organofluorine compounds. However, enzymatic methods for C–F bond formation have been limited to nucleophilic fluoride substitution. Here we report the incorporation of iron-catalysed radical fluorine transfer, a reaction mechanism that is not used in naturally occurring enzymes, into enzymatic catalysis for the development of biocatalytic enantioselective C(sp3)–F bond formation.

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Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer - Nature Synthesis

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Engineering non-haem iron enzymes for enantioselective C(sp3)–F bond formation via radical fluorine transfer - Nature Synthesis

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