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The covariance environment defines cellular niches for spatial inference - Nature Biotechnology

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The covariance environment defines cellular niches for spatial inference - Nature Biotechnology

A key challenge of analyzing data from high-resolution spatial profiling technologies is to suitably represent the features of cellular neighborhoods or niches. Here we introduce the covariance environment (COVET), a representation that leverages the gene–gene covariate structure across cells in the niche to capture the multivariate nature of cellular interactions within it. We define a principled optimal transport-based distance metric between COVET niches that scales to millions of cells.

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The covariance environment defines cellular niches for spatial inference - Nature Biotechnology

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The covariance environment defines cellular niches for spatial inference - Nature Biotechnology

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