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Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors - Neuropsychopharmacology

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Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors - Neuropsychopharmacology

Clinical studies have shown that the mediodorsal thalamus (MD) may play an important role in the development of depression. However, the molecular and circuit mechanisms by which the mediodorsal thalamus (MD) participates in the pathological processes of depression remain unclear. Here, we show that in male chronic social defeat stress (CSDS) mice, the calcium signaling activity of glutamatergic neurons in MD is reduced.

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Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors - Neuropsychopharmacology

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Mediodorsal thalamus projection to medial prefrontal cortical mediates social defeat stress-induced depression-like behaviors - Neuropsychopharmacology

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Unlocking the Power of Knowledge
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