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Structural basis of exoribonuclease-mediated mRNA transcription termination - Nature

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Structural basis of exoribonuclease-mediated mRNA transcription termination - Nature

Efficient termination is required for robust gene transcription. Eukaryotic organisms use a conserved exoribonuclease-mediated mechanism to terminate the mRNA transcription by RNA polymerase II (Pol II)1–5. Here we report two cryogenic electron microscopy structures of Saccharomyces cerevisiae Pol II pre-termination transcription complexes bound to the 5′-to-3′ exoribonuclease Rat1 and its partner Rai1.

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Structural basis of exoribonuclease-mediated mRNA transcription termination - Nature

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Structural basis of exoribonuclease-mediated mRNA transcription termination - Nature

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