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High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome - Nature Structural & Molecular Biology

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High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome - Nature Structural & Molecular Biology

Cryo-electron microscopy of brain tissue from two individuals with Down syndrome showed amyloid-β (Aβ) and tau filaments identical to those found in individuals with sporadic or dominantly inherited Alzheimer disease (AD), but also two types of Aβ40 filaments with distinct structures different from those previously reported in AD and cerebral amyloid angiopathy.

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High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome - Nature Structural & Molecular Biology

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High-resolution structures of amyloid-β and tau aggregates in individuals with Down syndrome - Nature Structural & Molecular Biology

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