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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome - Nature Structural & Molecular Biology

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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome - Nature Structural & Molecular Biology

Adult individuals with Down syndrome (DS) develop Alzheimer disease (AD). Whether there is a difference between AD in DS and AD regarding the structure of amyloid-β (Aβ) and tau filaments is unknown. Here we report the structure of Aβ and tau filaments from two DS brains. We found two Aβ40 filaments (types IIIa and IIIb) that differ from those previously reported in sporadic AD and two types of Aβ42 filaments (I and II) identical to those found in sporadic and familial AD.

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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome - Nature Structural & Molecular Biology

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Cryo-EM structures of amyloid-β and tau filaments in Down syndrome - Nature Structural & Molecular Biology

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