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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 - Cell Death & Differentiation

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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 - Cell Death & Differentiation

Necroptosis is a lytic form of cell death that is mediated by the kinase RIPK3 and the pseudokinase MLKL when caspase-8 is inhibited downstream of death receptors, toll-like receptor 3 (TLR3), TLR4, and the intracellular Z-form nucleic acid sensor ZBP1. Oligomerization and activation of RIPK3 is driven by interactions with the kinase RIPK1, the TLR adaptor TRIF, or ZBP1.

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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 - Cell Death & Differentiation

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ZBP1 and TRIF trigger lethal necroptosis in mice lacking caspase-8 and TNFR1 - Cell Death & Differentiation

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