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Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles - Nature Chemistry

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Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles - Nature Chemistry

Chiral α-tertiary amines and related azacycles are sought-after compounds for drug development. Despite progress in the catalytic asymmetric construction of aza-quaternary stereocentres, enantioselective synthesis of multifunctional α-tertiary amines remains underdeveloped. Enantioenriched α-disubstituted α-ethynylamines are attractive synthons for constructing chiral α-tertiary amines and azacycles, but methods for their catalytic enantioselective synthesis need to be expanded.

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Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles - Nature Chemistry

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Enantioselective propargylic amination and related tandem sequences to α-tertiary ethynylamines and azacycles - Nature Chemistry

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