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Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site - Nature

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Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site - Nature

RAD51 is the central eukaryotic recombinase required for meiotic recombination and mitotic repair of double-strand DNA breaks (DSBs)1,2. However, the mechanism by which RAD51 functions at DSB sites in chromatin has remained elusive. Here we report the cryo-electron microscopy structures of human RAD51–nucleosome complexes, in which RAD51 forms ring and filament conformations.

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Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site - Nature

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Cryo-EM structures of RAD51 assembled on nucleosomes containing a DSB site - Nature

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