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Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma - Oncogenesis

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Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma - Oncogenesis

Endocrine receptors play an essential role in tumor metabolic reprogramming and represent a promising therapeutic avenue in pancreatic ductal adenocarcinoma (PDAC). PDAC is characterized by a nutrient-deprived microenvironment. To meet their ascendant energy demands, cancer cells can internalize extracellular proteins via macropinocytosis. However, the roles of endocrine receptors in macropinocytosis are not clear.

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Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma - Oncogenesis

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Progesterone receptor potentiates macropinocytosis through CDC42 in pancreatic ductal adenocarcinoma - Oncogenesis

Rate This Post

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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