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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes - Nature Biomedical Engineering

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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes - Nature Biomedical Engineering

The killing function of cytotoxic T cells can be enhanced biochemically. Here we show that blocking the mechanical sensor PIEZO1 in T cells strengthens their traction forces and augments their cytotoxicity against tumour cells. By leveraging cytotoxic T cells collected from tumour models in mice and from patients with cancers, we show that PIEZO1 upregulates the transcriptional factor GRHL3, which in turn induces the expression of the E3 ubiquitin ligase RNF114.

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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes - Nature Biomedical Engineering

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PIEZO1 mechanically regulates the antitumour cytotoxicity of T lymphocytes - Nature Biomedical Engineering

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