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Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq - Communications Biology

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Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq - Communications Biology

Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes. Although the structure of the M3-miniGq complex was recently published, the lack of information on the intracellular loop 3 (ICL3) of M3 and extensive modification of Gαq impedes the elucidation of the molecular mechanism of M3-Gq coupling under more physiological condition.

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Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq - Communications Biology

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Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq - Communications Biology

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