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A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds - Nature Chemistry

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A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds - Nature Chemistry

A compound's overall contour impacts its ability to elicit biological response, rendering access to distinctly shaped molecules desirable. A natural product's framework can be modified, but only if it is abundant and contains suitably modifiable functional groups. Here we introduce a programmable strategy for concise synthesis of precisely altered scaffolds of scarce bridged polycyclic alkaloids.

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A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds - Nature Chemistry

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A catalytic process enables efficient and programmable access to precisely altered indole alkaloid scaffolds - Nature Chemistry

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