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Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination - Scientific Reports

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Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination - Scientific Reports

Scribble is a master scaffold protein in apical-basal polarity. Current knowledge about the biological function of Scribble in colonic epithelial plasticity/regeneration during intestinal inflammation is limited. Here, we showed that the level of Scribble is decreased in inflammatory bowel disease (IBD) patients and mice with DSS-induced colitis. ScribΔIEC mice develops severe acute colitis with disrupted epithelial barrier integrity and impaired crypt stem cell's function.

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Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination - Scientific Reports

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Scribble deficiency mediates colon inflammation by inhibiting autophagy-dependent oxidative stress elimination - Scientific Reports

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