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A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson's disease–associated glial changes - Nature Aging

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A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson's disease–associated glial changes - Nature Aging

Age is the primary risk factor for Parkinson's disease (PD), but how aging changes the expression and regulatory landscape of the brain remains unclear. Here we present a single-nuclei multiomic study profiling shared gene expression and chromatin accessibility of young, aged and PD postmortem midbrain samples. Combined multiomic analysis along a pseudopathogenesis trajectory reveals that all glial cell types are affected by age, but microglia and oligodendrocytes are further altered in PD.

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A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson's disease–associated glial changes - Nature Aging

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A single-nuclei paired multiomic analysis of the human midbrain reveals age- and Parkinson's disease–associated glial changes - Nature Aging

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for Humanity's Progress