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USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy - Cell Death & Differentiation

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USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy - Cell Death & Differentiation

Drug resistance in cancer therapy is the major reason for poor prognosis. Addressing this clinically unmet issue is important and urgent. In this study, we found that targeting USP24 by the specific USP24 inhibitors, USP24-i and its analogues, dramatically activated autophagy in the interphase and mitotic periods of lung cancer cells by inhibiting E2F4 and TRAF6, respectively.

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USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy - Cell Death & Differentiation

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USP24-i-101 targeting of USP24 activates autophagy to inhibit drug resistance acquired during cancer therapy - Cell Death & Differentiation

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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