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Precise and scalable self-organization in mammalian pseudo-embryos - Nature Structural & Molecular Biology

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Precise and scalable self-organization in mammalian pseudo-embryos - Nature Structural & Molecular Biology

Gene expression is inherently noisy, posing a challenge to understanding how precise and reproducible patterns of gene expression emerge in mammals. Here we investigate this phenomenon using gastruloids, a three-dimensional in vitro model for early mammalian development. Our study reveals intrinsic reproducibility in the self-organization of gastruloids, encompassing growth dynamics and gene expression patterns.

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Precise and scalable self-organization in mammalian pseudo-embryos - Nature Structural & Molecular Biology

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Precise and scalable self-organization in mammalian pseudo-embryos - Nature Structural & Molecular Biology

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