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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates - Nature Chemistry

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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates - Nature Chemistry

Several RNA binding proteins involved in membraneless organelles can form pathological amyloids associated with neurodegenerative diseases, but the mechanisms of how this aggregation is modulated remain elusive. Here we investigate how heterotypic protein–RNA interactions modulate the condensation and the liquid to amyloid transition of hnRNPA1A, a protein involved in amyothropic lateral sclerosis.

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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates - Nature Chemistry

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RNA modulates hnRNPA1A amyloid formation mediated by biomolecular condensates - Nature Chemistry

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