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Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination - Nature Nanotechnology

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Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination - Nature Nanotechnology

Multivalent presentation of ligands often enhances receptor activation and downstream signalling. DNA origami offers a precise nanoscale spacing of ligands, a potentially useful feature for therapeutic nanoparticles. Here we use a square-block DNA origami platform to explore the importance of the spacing of CpG oligonucleotides. CpG engages Toll-like receptors and therefore acts to activate dendritic cells.

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Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination - Nature Nanotechnology

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Fine tuning of CpG spatial distribution with DNA origami for improved cancer vaccination - Nature Nanotechnology

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