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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake - Nature Metabolism

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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake - Nature Metabolism

Ghrelin, produced mainly by gastric X/A-like cells, triggers a hunger signal to the central nervous system to stimulate appetite. It remains unclear whether X/A-like cells sense gastric distention and thus regulate ghrelin production. Here we show that PIEZO1 expression in X/A-like cells decreases in patients with obesity when compared to controls, whereas it increases after sleeve gastrectomy.

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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake - Nature Metabolism

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Gastric mechanosensitive channel Piezo1 regulates ghrelin production and food intake - Nature Metabolism

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