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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis - Nature Cell Biology

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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis - Nature Cell Biology

β-Propeller protein-associated neurodegeneration (BPAN) is a rare X-linked dominant disease, one of several conditions that manifest with neurodegeneration and brain iron accumulation. Mutations in the WD repeat domain 45 (WDR45) gene encoding WIPI4 lead to loss of function in BPAN but the cellular mechanisms of how these trigger pathology are unclear.

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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis - Nature Cell Biology

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Loss of WIPI4 in neurodegeneration causes autophagy-independent ferroptosis - Nature Cell Biology

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