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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain - Nature Biotechnology

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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain - Nature Biotechnology

Astrocytes, the most abundant glial cell type in the brain, are underrepresented in traditional cortical organoid models due to the delayed onset of cortical gliogenesis. Here we introduce a new glia-enriched cortical organoid model that exhibits accelerated astrogliogenesis. We demonstrated that induction of a gliogenic switch in a subset of progenitors enabled the rapid derivation of astroglial cells, which account for 25–31% of the cell population within 8–10 weeks of differentiation.

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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain - Nature Biotechnology

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Morphological diversification and functional maturation of human astrocytes in glia-enriched cortical organoid transplanted in mouse brain - Nature Biotechnology

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