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The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis - Cell Death & Differentiation

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The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis - Cell Death & Differentiation

Absent, small, or homeotic1-like (ASH1L) is a histone lysine methyltransferase that generally functions as a transcriptional activator in controlling cell fate. So far, its physiological relevance in bone homeostasis and osteoclast differentiation remains elusive. Here, by conditional deleting Ash1l in osteoclast progenitors of mice, we found ASH1L deficiency resulted in osteoporosis and potentiation of osteoclastogenesis in vivo and in vitro.

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The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis - Cell Death & Differentiation

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The histone methyltransferase ASH1L protects against bone loss by inhibiting osteoclastogenesis - Cell Death & Differentiation

Rate This Post

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Unlocking the Power of Knowledge
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Unlocking the Power of Knowledge
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