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Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells - Acta Pharmacologica Sinica

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Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells - Acta Pharmacologica Sinica

Telomere repeat binding factor 2 (TRF2), a critical element of the shelterin complex, plays a vital role in the maintenance of genome integrity. TRF2 overexpression is found in a wide range of malignant cancers, whereas its down-regulation could cause cell death. Despite its potential role, the selectively small-molecule inhibitors of TRF2 and its therapeutic effects on liver cancer remain largely unknown.

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Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells - Acta Pharmacologica Sinica

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Discovery of a selective TRF2 inhibitor FKB04 induced telomere shortening and senescence in liver cancer cells - Acta Pharmacologica Sinica

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