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A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer - Nature Genetics

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A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer - Nature Genetics

Available genetically defined cancer models are limited in genotypic and phenotypic complexity and underrepresent the heterogeneity of human cancer. Here, we describe a combinatorial genetic strategy applied to an organoid transformation assay to rapidly generate diverse, clinically relevant bladder and prostate cancer models.

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A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer - Nature Genetics

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A combinatorial genetic strategy for exploring complex genotype–phenotype associations in cancer - Nature Genetics

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