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LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance - Oncogene

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LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance - Oncogene

Therapeutic resistance and metastasis largely contribute to mortality from breast cancer and therefore understanding the underlying mechanisms of such remains an urgent challenge. By cross-analysis of TCGA and GEO databases, LINC00460 was identified as an oncogenic long non-coding RNA, highly expressed in Doxorubicin resistant breast cancer. LINC00460 was further demonstrated to promote stem cell-like and epithelial-mesenchymal transition (EMT) characteristics in breast cancer cells.

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LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance - Oncogene

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LINC00460-FUS-MYC feedback loop drives breast cancer metastasis and doxorubicin resistance - Oncogene

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