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CST–polymerase α-primase solves a second telomere end-replication problem - Nature

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CST–polymerase α-primase solves a second telomere end-replication problem - Nature

Telomerase adds G-rich telomeric repeats to the 3′ ends of telomeres1, counteracting telomere shortening caused by loss of telomeric 3′ overhangs during leading-strand DNA synthesis ('the end-replication problem'2). Here we report a second end-replication problem that originates from the incomplete duplication of the C-rich telomeric repeat strand (C-strand) by lagging-strand DNA synthesis.

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CST–polymerase α-primase solves a second telomere end-replication problem - Nature

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CST–polymerase α-primase solves a second telomere end-replication problem - Nature

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