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Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression - Nature Metabolism

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Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression - Nature Metabolism

Ageing increases susceptibility to neurodegenerative disorders, such as Alzheimer's disease (AD). Serum levels of sclerostin, an osteocyte-derived Wnt–β-catenin signalling antagonist, increase with age and inhibit osteoblastogenesis. As Wnt–β-catenin signalling acts as a protective mechanism for memory, we hypothesize that osteocyte-derived sclerostin can impact cognitive function under pathological conditions.

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Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression - Nature Metabolism

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Osteocyte-derived sclerostin impairs cognitive function during ageing and Alzheimer's disease progression - Nature Metabolism

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