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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation - Nature

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation - Nature

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2′3′-cyclic GMP-AMP (cGAMP)1–7. The indiscriminate activity of cGAS towards DNA demands tight regulatory mechanisms that are necessary to maintain cell and tissue homeostasis under normal conditions.

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation - Nature

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The CRL5–SPSB3 ubiquitin ligase targets nuclear cGAS for degradation - Nature

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