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Differential requirements for Smarca5 expression during hematopoietic stem cell commitment - Communications Biology

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Differential requirements for Smarca5 expression during hematopoietic stem cell commitment - Communications Biology

The formation of hematopoietic cells relies on the chromatin remodeling activities of ISWI ATPase SMARCA5 (SNF2H) and its complexes. The Smarca5 null and conditional alleles have been used to study its functions in embryonic and organ development in mice. These mouse model phenotypes vary from embryonic lethality of constitutive knockout to less severe phenotypes observed in tissue-specific Smarca5 deletions, e.g., in the hematopoietic system.

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Differential requirements for Smarca5 expression during hematopoietic stem cell commitment - Communications Biology

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Differential requirements for Smarca5 expression during hematopoietic stem cell commitment - Communications Biology

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