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Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS - Communications Biology

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Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS - Communications Biology

The fatal motor neuron (MN) disease Amyotrophic Lateral Sclerosis (ALS) is characterized by progressive MN degeneration. Phrenic MNs (phMNs) controlling the activity of the diaphragm are prone to degeneration in ALS, leading to death by respiratory failure. Understanding of the mechanisms of phMN degeneration in ALS is limited, mainly because human experimental models to study phMNs are lacking.

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Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS - Communications Biology

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Generation of human iPSC-derived phrenic-like motor neurons to model respiratory motor neuron degeneration in ALS - Communications Biology

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